Retooling Pap test to spot more kinds of cancer

WASHINGTON (AP) — For years, doctors have lamented that there's no Pap test for deadly ovarian cancer. Wednesday, scientists reported encouraging signs that one day, there might be.

Researchers are trying to retool the Pap, a test for cervical cancer that millions of women get, so that it could spot early signs of other gynecologic cancers, too.

How? It turns out that cells can flake off of tumors in the ovaries or the lining of the uterus, and float down to rest in the cervix, where Pap tests are performed. These cells are too rare to recognize under the microscope. But researchers from Johns Hopkins University used some sophisticated DNA testing on the Pap samples to uncover the evidence — gene mutations that show cancer is present.

In a pilot study, they analyzed Pap smears from 46 women who already were diagnosed with either ovarian or endometrial cancer. The new technique found all the endometrial cancers and 41 percent of the ovarian tumors, the team reported Wednesday in the journal Science Translational Medicine.

This is very early-stage research, and women shouldn't expect any change in their routine Paps. It will take years of additional testing to prove if the so-called PapGene technique really could work as a screening tool, used to spot cancer in women who thought they were healthy.

"Now the hard work begins," said Hopkins oncologist Dr. Luis Diaz, whose team is collecting hundreds of additional Pap samples for more study and is exploring ways to enhance the detection of ovarian cancer.

But if it ultimately pans out, "the neat part about this is, the patient won't feel anything different," and the Pap wouldn't be performed differently, Diaz added. The extra work would come in a lab.

The gene-based technique marks a new approach toward cancer screening, and specialists are watching closely.

"This is very encouraging, and it shows great potential," said American Cancer Society genetics expert Michael Melner.

"We are a long way from being able to see any impact on our patients," cautioned Dr. Shannon Westin of the University of Texas MD Anderson Cancer Center. She reviewed the research in an accompanying editorial, and said the ovarian cancer detection would need improvement if the test is to work.

But she noted that ovarian cancer has poor survival rates because it's rarely caught early. "If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality," Westin said.

More than 22,000 U.S. women are diagnosed with ovarian cancer each year, and more than 15,000 die. Symptoms such as pain and bloating seldom are obvious until the cancer is more advanced, and numerous attempts at screening tests have failed.

Endometrial cancer affects about 47,000 women a year, and kills about 8,000. There is no screening test for it either, but most women are diagnosed early because of postmenopausal bleeding.

The Hopkins research piggybacks on one of the most successful cancer screening tools, the Pap, and a newer technology used along with it. With a standard Pap, a little brush scrapes off cells from the cervix, which are stored in a vial to examine for signs of cervical cancer. Today, many women's Paps undergo an additional DNA-based test to see if they harbor the HPV virus, which can spur cervical cancer.

So the Hopkins team, funded largely by cancer advocacy groups, decided to look for DNA evidence of other gynecologic tumors. It developed a method to rapidly screen the Pap samples for those mutations using standard genetics equipment that Diaz said wouldn't add much to the cost of a Pap-plus-HPV test. He said the technique could detect both early-stage and more advanced tumors. Importantly, tests of Paps from 14 healthy women turned up no false alarms.

The endometrial cancers may have been easier to find because cells from those tumors don't have as far to travel as ovarian cancer cells, Diaz said. Researchers will study whether inserting the Pap brush deeper, testing during different times of the menstrual cycle, or other factors might improve detection of ovarian cancer.

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Irvine City Council overhauls oversight, spending on Great Park

Capping a raucous eight-hour-plus meeting, the Irvine City Council early Wednesday voted to overhaul the oversight and spending on the beleaguered Orange County Great Park while authorizing an audit of the more than $220 million that so far has been spent on the ambitious project.

A newly elected City Council majority voted 3 to 2 to terminate contracts with two firms that had been paid a combined $1.1 million a year for consulting, lobbying, marketing and public relations. One of those firms — Forde & Mollrich public relations — has been paid $12.4 million since county voters approved the Great Park plan in 2002.

"We need to stop talking about building a Great Park and actually start building a Great Park," council member Jeff Lalloway said.

The council, by the same split vote, also changed the composition of the Great Park's board of directors, shedding four non-elected members and handing control to Irvine's five council members.

The actions mark a significant turning point in the decade-long effort to turn the former El Toro Marine base into a 1,447-acre municipal park with man-made canyons, rivers, forests and gardens that planners hoped would rival New York's Central Park.

The city hoped to finish and maintain the park for years to come with $1.4 billion in state redevelopment funds. But that money vanished last year as part of the cutbacks to deal with California's massive budget deficit.

"We've gone through $220 million, but where has it gone?" council member Christina Shea said of the project's initial funding from developers in exchange for the right to build around the site. "The fact of the matter is the money is almost gone. It can't be business as usual."

The council majority said the changes will bring accountability and efficiencies to a project that critics say has been larded with wasteful spending and no-bid contracts. For all that has been spent, only about 200 acres of the park has been developed and half of that is leased to farmers.

But council members Larry Agran and Beth Krom, who have steered the course of the project since its inception, voted against reconfiguring the Great Park's board of directors and canceling the contracts with the two firms.

Krom has called the move a "witch hunt" against her and Agran. Feuding between liberal and conservative factions on the council has long shaped Irvine politics.

"This is a power play," she said. "There's a new sheriff in town."

The council meeting stretched long into the night, with the final vote coming Wednesday at 1:34 a.m. Tensions were high in the packed chambers with cheering, clapping and heckling coming from the crowd.

At one point council member Lalloway lamented that he "couldn't hear himself think."

During public comments, newly elected Orange County Supervisor Todd Spitzer chastised the council for "fighting like schoolchildren." Earlier this week he said that if the Irvine's new council majority can't make progress on the Great Park, he would seek a ballot initiative to have the county take over.

And Spitzer angrily told Agran that his stewardship of the project had been a failure.

"You know what?" he said. "It's their vision now. You're in the minority."

mike.anton@latimes.com

rhea.mahbubani@latimes.com

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News Analysis: Obama Nominees in Step on Light Footprint

Carolyn Kaster/Associated Press

President Obama named John O. Brennan, right, as his choice for C.I.A. director and chose Chuck Hagel, left, to be his next defense secretary.

WASHINGTON — With the selection of a new national security team deeply suspicious of the wisdom of American military interventions around the world, President Obama appears to have ended, at least for the moment, many of the internal administration debates that played out in the Situation Room over the past four years.

He has sided, without quite saying so, with Vice President Joseph R. Biden Jr.’s view — argued, for the most part, in the confines of the White House — that caution, covert action and a modest American military footprint around the world fit the geopolitical moment. The question is whether that approach will fit the coming challenges of stopping Iran’s nuclear program and the potential collapse of Syria.

Gone for the second term are the powerful personalities, and more hawkish voices, that pressed Mr. Obama to pursue the surge in Afghanistan in 2009, a gamble championed by Secretary of State Hillary Rodham Clinton and Robert M. Gates, the former secretary of defense. Gone from the C.I.A. is the man who urged Mr. Obama to keep troops there longer, David H. Petraeus.

The new team will include two Vietnam veterans, Senator John Kerry and Chuck Hagel, who bear the scars of a war that ended when the president was a teenager, and a counterterrorism chief, John O. Brennan, who helped devise the “light footprint” strategy of limiting American interventions, whenever possible, to drones, cyberattacks and Special Operations forces. All are advocates of those low-cost, low-American-casualty tools, and all have sounded dismissive of attempts to send thousands of troops to rewire foreign nations as wasteful and ill-conceived.

Most important to Mr. Obama and his national security adviser, Tom Donilon, all three are likely to accommodate themselves, in ways their predecessors often did not, to a White House that has insisted on running national security policy from the West Wing.

“One of the characteristics of this administration has been that decision-making has been centered in the White House,” said Dennis B. Ross, a Mideast expert who left the Obama administration a year ago but never wandered far from some of its key debates. “And most second-term administrations don’t change their sociology.”

But if they grab hold of the national security levers after what many predict will be, for Mr. Hagel and Mr. Brennan, bruising confirmation hearings, they will confront problems that may test whether the light footprint carries enough weight.

“Issues 1 and 2 will be cutting the defense budget and confronting Iran,” said Michael Mandelbaum, a political scientist whose 2010 book, “The Frugal Superpower,” dealt with the challenge of trying to manage the world on the cheap. “And then you will have issues like Syria, which test the question of whether you can manage to control a dangerous situation with no boots on the ground — and unless something dramatic changes, there will be no boots.”

Mr. Hagel, who was both a senator and a cellphone entrepreneur, has long been a critic of Pentagon bloat. But others with business experience, like Donald Rumsfeld, have believed they could bring market discipline to one of the country’s most sprawling enterprises, only to discover that killing off unneeded weapons systems has almost nothing to do with business decisions and everything to do with the politics of Congressional districts and campaign funds.

Mr. Obama’s bet was that by appointing a Republican, he will better his chances of overcoming those obstacles. What he discovered even before announcing Mr. Hagel’s appointment is that the former senator burned many bridges with his Republican colleagues, in part with his outspoken opposition to the Iraq war, despite voting in 2002 to authorize military action, and to the 2008 surge when President George W. Bush was still in office.

“If the president thinks Chuck Hagel can get him the Republican votes to downsize the Pentagon,” said one former senior aide to Mr. Bush, who declined to speak on the record, “I think he is in for a very rude surprise.”

Then there is Iran, which will be a test for all three men, for different reasons. Mr. Hagel has been particularly vocal about the dangers of a military confrontation with Tehran. While both Mr. Gates and his successor, Leon E. Panetta, expressed similar concerns at various points in the first term, Mr. Hagel’s view is considerably to the left of Mr. Obama’s. The president has, gradually, endorsed “coercive diplomacy,” telling the American Israel Public Affairs Committee in March, “As I’ve made clear time and again during the course of my presidency, I will not hesitate to use force when it is necessary to defend the United States and its interests.”

But Mr. Hagel has opposed unilateral sanctions and suggested that threatening Iran just closes down opportunities for dialogue.

“The key to coercive diplomacy is that the side you are trying to influence is convinced you are willing to follow through on the threat,” said Mr. Ross, who drafted some of those threats. “The president has been clear, but from others there have been mixed messages.”

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Panasonic considers headcount savings, asset sales in revival plan

LAS VEGAS (Reuters) – Japan‘s Panasonic Corp may see its headcount fall further and may sell non-core money-making business units to raise cash, president Kazuhiro Tsuga told reporters at the CES consumer electronics show in Las Vegas on Tuesday.

Hammered by competition from South Korean rivals such as Samsung Electronics, Panasonic may also squeeze wages and seek joint ventures in its semiconductors and other struggling operations in a bid to rekindle profit growth, Tsuga said.

Shares in Panasonic slipped 1.4 percent to a two-week low in Tokyo morning trade, compared to a 0.4 percent increase on the benchmark Nikkei average.

The Panasonic chief said in an earlier keynote speech he would pursue strategies to expand business-to-business sales of car batteries, in-flight entertainment systems, hydrogen cells, solar panels and LED lighting.

Japan’s share of the world’s flat panel TV market this year likely contracted to 31 percent compared with 41 percent in 2010, according to the Japan Electronics and Information Technology Industries Association.

Panasonic earlier unveiled a prototype of the world’s largest organic light-emitting display screen in a show of technological one-upmanship with its South Korean rivals Samsung and LG Electronics Inc.

Sony Corp, which is cooperating with Panasonic in OLED technology, unwrapped on Monday its own 56-inch ultra high-definition model.

Tsuga, who heads Japan’s biggest commercial employer with 300,000 staff, is also pursuing a niche strategy and bolstering the company’s appliance business in a bid to capture more profitable markets while the likes of Samsung and Apple Inc slug it out in mass-market consumer electronics.

The executive has promised to deliver the details of the revival plan by the end of March, when he plans to reorganize 88 businesses into 56 units.

So far he has said that businesses that fail to achieve a 5 percent operating margin within two years will be shuttered or sold. Sales of the weakest ones may start next business year. Panasonic in the year to March 31 is forecasting a net loss of $ 8.9 billion.

(Reporting by Tim Kelly; Editing by Paul Tait and Muralikumar Anantharaman)

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Beyoncé & Kelly Clarkson to Sing for the Obamas at Presidential Inauguration

01/09/2013 at 05:00 AM EST

From left: Beyoncé, Kelly Clarkson and James Taylor, with President Obama (inset)

Celebrity Photo; Getty; Filmmagic. Inset: Landov

Michelle Obama works out to her music – plus, she's no stranger to the White House – so it's only fitting this year that Beyoncé will be front and center at President Barack Obama's inauguration.

The R&B superstar will be performing the National Anthem at the Jan. 21 ceremony, which will take place at the West Front of the U.S. Capitol, the Presidential Inaugural Committee tells PEOPLE. And she will be joined by an equally auspicious roster of singers: Kelly Clarkson will perform "My Country 'Tis of Thee" this year (that honor went to Aretha Franklin ... and her infamous hat in 2009), while James Taylor will sing "America the Beautiful."

In 2009, Beyoncé performed Etta James's classic, "At Last," while the President and Michelle Obama took their first dance during the Neighborhood Inaugural Ball.

Other inaugural ceremony participants include civil rights activist and journalist Myrlie Evers-Williams, who will give the invocation. Reverend Louie Giglio will deliver the benediction.

According to the Presidential Inaugural Committee, more information about ceremonial participants will be released in the coming days. Could Aretha be back for her encore?

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Report: Death rates from cancer still inching down

WASHINGTON (AP) — Death rates from cancer are continuing to inch down, researchers reported Monday.

Now the question is how to hold onto those gains, and do even better, even as the population gets older and fatter, both risks for developing cancer.

"There has been clear progress," said Dr. Otis Brawley of the American Cancer Society, which compiled the annual cancer report with government and cancer advocacy groups.

But bad diets, lack of physical activity and obesity together wield "incredible forces against this decline in mortality," Brawley said. He warned that over the next decade, that trio could surpass tobacco as the leading cause of cancer in the U.S.

Overall, deaths from cancer began slowly dropping in the 1990s, and Monday's report shows the trend holding. Among men, cancer death rates dropped by 1.8 percent a year between 2000 and 2009, and by 1.4 percent a year among women. The drops are thanks mostly to gains against some of the leading types — lung, colorectal, breast and prostate cancers — because of treatment advances and better screening.

The news isn't all good. Deaths still are rising for certain cancer types including liver, pancreatic and, among men, melanoma, the most serious kind of skin cancer.

Preventing cancer is better than treating it, but when it comes to new cases of cancer, the picture is more complicated.

Cancer incidence is dropping slightly among men, by just over half a percent a year, said the report published by the Journal of the National Cancer Institute. Prostate, lung and colorectal cancers all saw declines.

But for women, earlier drops have leveled off, the report found. That may be due in part to breast cancer. There were decreases in new breast cancer cases about a decade ago, as many women quit using hormone therapy after menopause. Since then, overall breast cancer incidence has plateaued, and rates have increased among black women.

Another problem area: Oral and anal cancers caused by HPV, the sexually transmitted human papillomavirus, are on the rise among both genders. HPV is better known for causing cervical cancer, and a protective vaccine is available. Government figures show just 32 percent of teen girls have received all three doses, fewer than in Canada, Britain and Australia. The vaccine was recommended for U.S. boys about a year ago.

Among children, overall cancer death rates are dropping by 1.8 percent a year, but incidence is continuing to increase by just over half a percent a year. Brawley said it's not clear why.

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Charlie Sheen downplays Baja encounter with L.A. mayor

Los Angeles Mayor Antonio Villaraigosa found himself sucked deeper into the Charlie Sheen-TMZ-Hollywood gossip vortex Tuesday, with the actor speaking out again about the night they met up at a hotel in Mexico over the holidays.

Sheen made news last month after he tweeted a picture of himself with his arm around Villaraigosa the night of Sheen's bar opening in Baja California, Mexico. The former star of "Two and a Half Men" praised the mayor as a man who "knows how to party." But Villaraigosa downplayed the significance of the image, telling KNBC's Conan Nolan over the weekend that he had only "bumped into" Sheen and engaged in a three-minute conversation.

On Tuesday, Sheen challenged Villaraigosa's account, telling celebrity website TMZ that the mayor was drinking in Sheen's hotel suite in a room full of beautiful women, including at least one porn star. "I memorize 95 pages a week, so the last thing that I am is memory challenged," Sheen told the website. "We hung out for the better part of two hours."

Hours later, Sheen issued a more muted account, saying the mayor had spoken to many other people at the opening of the bar. "I am a giant fan of the mayor's and apologize if any of my words have been misconstrued," the statement said.

By then, however, Villaraigosa found himself fending off related questions at a news conference meant to be devoted to billionaire Eli Broad's new downtown art museum. "Can you just set the record straight for us?" asked one reporter. "What was it? Two hours or three minutes?" asked another. Then came the zinger: "Does what happens in Cabo stay in Cabo?"

Villaraigosa cackled at the Cabo crack but refused to take the bait. "I've said what I'm going to say on that, everybody," Villaraigosa declared. "You had fun. Let's talk about the important things, like a thousand jobs today" — a reference to construction work going on at Broad's museum.

Villaraigosa has frequently bristled at media questions about his personal life, going silent on some occasions and becoming visibly angry on others. Last week, he told KNBC's Nolan that Nolan had asked a "bozo question" about the Sheen photograph. He also noted that Nolan and other newsroom staffers have, like Sheen, asked the mayor to pose for pictures with them.

Sheen has been a TMZ staple, using the website as a platform to talk up his $100,000 gift to celebrity Lindsay Lohan and his porn star "goddesses." And Villaraigosa has glided easily between the world of politics and the entertainment industry since being elected in 2005.

"He's a celebrity mayor. And he's always wanted to be that," said Jaime Regalado, professor emeritus of political science at Cal State L.A. "If you're going to be a celebrity mayor, you have to take the good and the bad and everything in between" when it comes to news coverage.

david.zahniser@latimes.com

kate.linthicum@latimes.com

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Faceoff in Chinese City Over Censorship of Newspaper

Jonah M. Kessel for The New York Times

A free speech advocate outside of Southern Weekend newspaper in Guangzhou, China, on Tuesday.

GUANGZHOU, China – Protests over censorship at one of China’s most liberal newspapers descended into ideological confrontation on Tuesday, pitting advocates of free speech against supporters of Communist Party control who wielded red flags and portraits of Mao Zedong.

The face-off between liberals and leftists at the headquarters of a newspaper company in southern China came after disgruntled editors and reporters at Southern Weekend last week decried what they alleged was crude meddling by the head of party propaganda in Guangdong Province, which has long had a reputation as a bastion of a relatively free press.

Negotiations between journalists and officials over the dispute are still at a standoff as the newspaper’s next publication date on Thursday looms, said Chen Min, a former senior writer for the paper.

Senior Chinese officials have so far not commented in public on the censorship dispute at the newspaper, which has tested how far the recently appointed Communist Party leader Xi Jinping will extend his vows of economic reform into a degree of political relaxation. But self-proclaimed defenders of communist orthodoxy who turned up at the newspaper headquarters said they were there to make the party’s case.

“We support the Communist Party, shut down the traitor newspaper,” said one of the cardboard signs held up by one of ten or so protesters who came to defend the government.

“Southern Weekend is having an American dream,” said another of the signs. “We don’t want the American dream, we want the Chinese dream.”

Some of the group held up portraits of Mao Zedong, the late revolutionary leader who remains a symbol of communist zeal, while others waved the red flags of the People’s Republic of China and the Chinese Communist Party. Most of the party supporters refused to give their names. They said they came on their own initiative, and not at the behest of officials.

The dueling protests outside the newspaper’s headquarters in this provincial capital reflected the political passions and tensions churned up by the quarrel over censorship, which has erupted while Mr. Xi is trying to win public favor and consolidate his authority.

Hundreds of bystanders watched and took photos on smart phones as the leftists shouted at the 20 or more protesters who had gathered to denounce censorship, and shoving matches broke out between the demonstrators.

At one point, leftists were showered with 50-cent renminbi currency notes. The “Fifty Cent Party” has become a popular term for disparaging pro-party leftists, who are alleged by critics to be willing to take 50 cents in payment for each pro-party message they send onto the Internet.

“It’s the only newspaper in China that’s willing to tell the truth,” said Liang Taiping, 28, a poet from Changsha in southern China, who said he took the train to Guangzhou to show his support for Southern Weekend, which is widely read nationwide.

“What’s the point of living while you can’t even speak freely?” he said.

About 70 police officers and security guards stood nearby. They did not try to break up the protests, but officers recorded them with video cameras and occasionally stepped in to stop shoving and fisticuffs. Later, the rival protesters broke into separate camps concentrated on different sides of the gate to the newspaper headquarters.

The protesting journalists at Southern Weekend have also called for the dismissal of Tuo Zhen, the top propaganda official in Guangdong Province.

They blame Mr. Tuo, a former journalist, for making a drastic change in a New Year’s editorial that originally called for greater respect for constitutional rights. The revised editorial instead lauded Communist Party’s policies.

Chen Min, a prominent former opinion writer for Southern Weekend who is better known by his pen name, Xiao Shu, said staff members at the newspaper have been negotiating with officials over a possible solution to the standoff that might allow the next issue to appear on Thursday, as usual.

The protests at Southern Weekend broke out while Mr. Xi, the party’s general secretary appointed in November, has been sending mixed signals about his intentions. He has repeatedly said he supports faster and bolder reform, but on Saturday he gave a speech defending the party’s history and Mao Zedong’s standing in it.

China’s Central Propaganda Department, which administers the censorship apparatus, issued instructions telling news media that the dispute at Southern Weekend was “due to the meddling of hostile outside forces,” according to China Digital Times, a group based in Berkeley, Calif., that monitors media and censorship issues.

Both supporters and critics of Southern Weekend journalists have claimed that Mr. Xi would back their cause.

“I don’t believe that Xi is totally hypocritical when he talks about reform,” said Mr. Chen, who was forced out of the newspaper in 2011.

“The Southern Weekend journalists have said that they accept party control, but the question is what kind of control and how far should it go unchallenged,” Mr. Chen added.

Jonah Kessel reported from Guangzhou, China, and Chris Buckley from Hong Kong. Mia Li contributed reporting from Guangzhou, and Patrick Zuo from Beijing.

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181,354 People on Twitter Think They’re Experts at Twitter

Do you tweet a lot? Do you post everything on Facebook? Do you #hashtag #complete #sentences #like #this? Do you describe yourself, variously, as a social media “maven”, “master”, “guru”, “freak”, “warrior”, “evangelist” or “veteran”? (Yes, a social media veteran. As if Tumblr were a deadly war you narrowly survived.) Well: you’ve got company! There are more than 181,000 such individuals on Twitter, people who adorn their profiles with credentials like “social media freak” and “social media wonk” and “social media authority.”

RELATED: Teens Hacking Their Friends’s Twitter Accounts Is All the Rage

B.L. Ochman at Advertising Age, whose heroic research produced the final tally, first noted the trend three years ago — when she recorded, among other distinctions, 68 “social media stars” and 79 “social media ninjas” on Twitter alone — and has been keeping track ever since. This isn’t just the stuff of legitimate Twitter news-breakers like Anthony DeRosa and Andy Carvin — Ohman provides a helpful breakdown of the terms she looked for — you know, like “social media warrior.” (We’re tempted to argue that such diligence makes Ochman something of a social media warrior herself.) Ochman also warns of using “guru” — a Sanskrit term — to describe oneself:

While a great many of these self-appointed gurus are no doubt taking the title with tongue firmly planted in cheek, the fact remains: a guru is something someone else calls you, not something you call yourself. Scratch that: let’s save “guru” (Sanskrit for “teacher”) for religious figures or at least people with real unique knowledge.

I’d argue, in fact, that “social media” and “guru” should never appear in the same sentence.

Whatever the term, social media seems to be a growth industry: there were only 15,740 “mavens” (or whatever) in 2009 — less than a tenth of those represented today.

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Justin Bartha Is Dating Trainer Lia Smith

01/07/2013 at 07:00 PM EST

Lia and Justin in Hawaii New Years Day

Pacific Coast News

Justin Bartha's "mystery woman" is in fact his girlfriend, trainer Lia Smith, a source reveals to PEOPLE.

The pair recently enjoyed a cozy trip to Smith's native Hawaii and were snapped basking in the sun on Maui on New Year's Day, which got people buzzing about her identity.

"They were very cute with each other," says an eyewitness. "They had their arms around each other and were kissing."

The couple also spent time with Smith's parents on Oahu. Bartha, who currently stars on The New Normal, was previously linked to Scarlett Johansson and dated Ashley Olsen for two years before breaking up in 2011.

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